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Anti- IDH2(R172H) Mouse Monoclonal Antibody

價格¥4800.00
品牌NewEast Biosciences   
產(chǎn)地中國 武漢
貨號26084
規(guī)格100ul
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  • IDH2(R172H) [26084]
    [100 µL]

     

    Catalog Number:  26084
    Gene Symbol:  IDH2
    Description:   Anti IDH2(R172H) Mouse Monoclonal Antibody
    Background:   Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Mutations of Arg-172 in IDH2 to Cys, His, Leu or Ser abolish magnesium binding and the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R-2-hydroxyglutarate. Elevated levels of R-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
    Immunogen:   A synthetic peptide from the internal region of human IDH2 which includes the mutation of R172H.
    Applications:   ELISA, WB, IHC, IF
    Recommended Dilutions:   
    ELISA: 1:1000-1:5000 
    WB: 1:100-1:1000 
    IHC: 1:50-1:100 
    IF: 1:50-1:100
    Concentration:   1 mg/ml
    Host:   mouse
    Format:   Liquid
    Clonality:   Monoclonal
    Isotype:   IgG
    Purity:   Purified from ascites
    Storage buffer:
    Preservative:  no
    Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
    Species Reactivity:  Anti-IDH2(R172H) antibody recognizes IDH2(R172H) of vertebrates.
    Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles.
     
    Western blot:  
    Western blot analysis of recombinant IDH2(R172H) and wild-type IDH2 proteins. Purified his-tagged IDH2(R172H) protein (Cat. # 10201) and wild-type IDH2 protein (Cat. # 10200) were blotted with anti IDH2(R172H) monoclonal antibody (Cat. # 26084) (left panel). Proteins loading were blotted with anti-IDH2 monoclonal antibody (right panel).
    Immunofluorescence:    
    Immunofluorescence of cells expressing IDH2 proteins with Anti IDH2(R172H) antibody. HEK293T cells were transfected with pCDNA3-GFP IDH2(WT) plasmid (left column) or pCDNA3-GFP IDH2(R172H) plasmid (right column), then fixed and stained with Anti IDH2(R172H) monoclonal antibody (Cat. #26084).

     

    Related Products
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    26163 Anti IDH2(R172K) Mouse Monoclonal Antibody 100 μL ¥4,800
    26408 Anti IDH2(R172S) Mouse Monoclonal Antibody  100 μL  ¥4800
    26165 Anti IDH2(R140Q) Mouse Monoclonal Antibody 100 μL ¥4,800
    26231 Anti IDH2(R172G) Mouse Monoclonal Antibody 100 μL ¥4,800
    26084 Anti IDH2(R172H) Mouse Monoclonal Antibody 100 μL  ¥4800

     

     

    Publications:
    1.  Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas
        Brain Tumor Pathology. January 2015, Volume 32, Issue 1, pp 3-11
    2.  Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer
        Nature 513, 110–114 (04 September 2014)
    3.  Metabolomic comparison between cells overexpressing isocitrate dehydrogenase 1 and 2 mutants and the effects of an inhibitor on the metabolism

        Journal of Neurochemistry. Volume 132, Issue 2, pages 183–193, January 2015

    4.Immunohistochemical analysis of IDH2 R172 hotspot mutations in breast papillary neoplasms: applications in the diagnosis of tall cell carcinoma with reverse polarity

       Fresia Pareja, Edaise M. da Silva, [..] Edi Brogi E  02 January 2020

     

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